Epstein Pearls – Symptoms and Treatment

What Are Epstein Pearls?

Epstein Pearls are small, white or yellowish cysts that commonly appear on a newborn's gums or the roof of their mouth. These tiny nodules are often mistaken for emerging teeth or oral thrush, but they are completely normal and harmless. They typically develop in about 60–85% of new-borns and do not cause any pain or discomfort.

Epstein Pearls form during fetal development when keratin, a protein found in the skin and mucous membranes, becomes trapped inside the oral tissue. As the baby’s mouth continues to develop, these small cysts can appear along the midline of the palate or along the gumline. Since they are a natural part of a baby’s growth, there is no need for medical intervention—these cysts tend to disappear on their own within a few weeks after birth. 

Causes of Epstein Pearls

Epstein Pearls are a common oral condition in newborns, and they develop as a natural part of fetal development. These small cysts are harmless and typically disappear on their own within a few weeks after birth. Understanding their causes can help parents feel reassured that Epstein Pearls are not a cause for concern.

1. A Natural Part of Oral Development in Utero

Epstein Pearls form during pregnancy as the baby's mouth and oral tissues develop. As the palate (roof of the mouth) and gums take shape, small keratin-filled cysts mayform along the gumline or the midline of the palate. These cysts are part of the normal developmental process and do not indicate any underlying health issues.

2. Caused by Trapped Epithelial Cells and Keratin

The primary cause of Epstein Pearls is trapped epithelial cells and keratin (a protein found in skin, hair, and nails). During oral development, some of these cells can get enclosed within the soft tissues of the mouth, forming small cyst-like bumps. Since keratin naturally accumulates in the skin and mucous membranes, its presence in the oral cavity can lead to the formation of Epstein Pearls.

Unlike other oral cysts, Epstein Pearls are not caused by infections, poor hygiene, or dietary factors. They are completely benign and do not cause pain or discomfort.

3. More Common in Newborns and Infants

Epstein Pearls are very common in newborns and infants, affecting up to 80% of babies. Since they are a standard part of fetal development, they are not linked to any genetic conditions or medical concerns.

Although Epstein Pearls are harmless and temporary, they may sometimes be confused with oral thrush (a fungal infection) or early tooth eruption. If parents are unsure about their baby’s oral condition, a pediatric dentist in Las Vegas can help provide a proper assessment and reassurance. 

Symptoms and Identification

Epstein Pearls are harmless oral cysts that appear in newborns and are often mistaken for other conditions such as thrush or natal teeth. Understanding their distinct characteristics can help parents recognize them and avoid unnecessary concern.

1. Painless, Small White Bumps on the Gums or Palate

One of the defining features of Epstein Pearls is their appearance. They typically look like:

  • Small, round, or slightly elongated white or yellowish cysts.
  • Located on the roof of the mouth (palate) or along the gumline.
  • Usually measure 1-3 millimeters in diameter.

These bumps do not grow or spread and will naturally disappear over time.

2. No Redness, Swelling, or Discomfort

Unlike other oral conditions, Epstein Pearls are completely painless and do not cause any discomfort to the baby. They do not:

❌ Cause redness or inflammation.
❌ Lead to swelling or tenderness.
❌ Interfere with feeding, sucking, or swallowing.

Since Epstein Pearls do not cause irritation, most babies remain completely unaware of them. Parents often notice them during routine feedings or while checking their baby’s mouth.

3. Disappear on Their Own Within a Few Weeks

Epstein Pearls require no treatment, as they will naturally go away. The cysts break down and get absorbed into the soft tissue of the mouth as the baby continues sucking, feeding, and using their tongue and gums.

💡 Most cases resolve within1-2 weeks, but some may take up to 3 months to completely disappear.

4. Not to Be Confused with Thrush or Natal Teeth

Epstein Pearls can sometimes be mistaken for other oral conditions, but there are key differences:

Since Epstein Pearls do not cause pain or interfere with feeding, they do not require medical intervention. However, if parents are concerned, a pediatric dentist in Las Vegas can help confirm the diagnosis.

 

Treatment and Home Care

Epstein Pearls are harmless and temporary, meaning no medical treatment is required. However, parents often wonder if they should take any steps to help their baby’s oral health. The good news is that Epstein Pearls disappear on their own within a few weeks. Here’s what you need to know about proper care and home management.

1. No Treatment is Necessary

Since Epstein Pearls naturally dissolve over time, there is no need for any medical treatment. The cysts will break down as the baby continues to feed, suck, and use their tongue and gums.

Most cases resolve within 1–2 weeks, though some may take up to 3 months.
✅ No medications, ointments, or special rinses are required.
✅ Pediatric dentists and doctors do not recommend any intervention.

2. Do Not Attempt to Pop or Remove Them

Parents may feel tempted to rub, pop, or scrape Epstein Pearls, but this should be avoided at all costs.

❌ Attempting to remove them can lead to irritation, bleeding, or infection.
❌ The baby’s oral tissues are delicate, and interfering with natural healing can cause unnecessary discomfort.
❌ Epstein Pearls are not like pimples or cysts—they are naturally occurring and will go away on their own.

3. Maintain Gentle Oral Hygiene

Even though Epstein Pearls do not require special treatment, it is still good practice to keep your baby’s mouth clean.

💡 Use a soft, clean washcloth or damp gauze to gently wipe the gums once a day.
💡 Avoid using toothpaste or mouthwash—newborns do not need them.
💡 Keeping your baby’s mouth clean helps prevent oral thrush or milk residue buildup, which can sometimes be mistaken for Epstein Pearls.

4. Encourage Breastfeeding or Bottle Feeding

There is no need to modify your baby’s feeding routine due to Epstein Pearls. Continue:

🍼 Breastfeeding or bottle feeding as usual—sucking naturally helps the cysts resolve.
🍼 Ensuring proper latch and positioning to support oral development.
🍼 Keeping a regular feeding schedule to promote gum health and circulation.

 

Epstein Pearls are harmless and usually do not require medical attention. However, parents should monitor their baby’s oral health and consult a pediatric dentist if there are any concerns. A professional check-up ensures peace of mind and sets the foundation for a lifetime of healthy smiles.

CALL 702-660-7099Back to All Posts